MYPT1 Protein Isoforms Are Differentially Phosphorylated by Protein Kinase G*
نویسندگان
چکیده
منابع مشابه
MYPT1 isoforms expressed in HEK293T cells are differentially phosphorylated after GTPγS treatment
Agonist stimulation of smooth muscle is known to activate RhoA/Rho kinase signaling, and Rho kinase phosphorylates the myosin targeting subunit (MYPT1) of myosin light chain (MLC) phosphatase at Thr696 and Thr853, which inhibits the activity of MLC phosphatase to produce a Ca2+ independent increase in MLC phosphorylation and force (Ca2+ sensitization). Alternative mRNA splicing produces four MY...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2011
ISSN: 0021-9258
DOI: 10.1074/jbc.m111.282905